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  1. Hot take: GPT 4.5 is a nothing burger (garymarcus.substack.com)
    255 points by isaacfrond 6 days ago | 280 comments
  2. The Dino, the Llama, and the Whale (Deno and Jupyter for Local AI Experiments) (deno.com)
    59 points by olestr 6 days ago | 14 comments
  3. A protein from tardigrades may help cancer patients tolerate radiation therapy (news.mit.edu)
    5 points by rbanffy 2 days ago | 1 comment
  4. Video encoding requires using your eyes (redvice.org)
    91 points by zdw 6 days ago | 48 comments
  5. They wanted to save us from a dark AI future. Then six people were killed (theguardian.com)
    80 points by Qision 15 hours ago | 54 comments
  6. Muon's magnetic moment exposes a hole in the Standard Model, unless it doesn't (physicsworld.com)
    83 points by ColinWright 6 days ago | 23 comments
  7. Understand the Joule Thief Circuit (electronics.stackexchange.com)
    5 points by red369 3 days ago | discuss
  8. A cross-platform multi-target dotfiles manager written in Rust (github.com)
    81 points by michidk 4 days ago | 82 comments
  9. World-first experimental cancer treatment paves way for clinical trial (wehi.edu.au)
    208 points by femto 6 days ago | 77 comments
  10. Thunderforge: Microsoft and Anduril AI Agents for American Defense (scale.com)
    6 points by Jimmc414 13 hours ago | 1 comment
  11. Write to Escape Your Default Setting (kupajo.com)
    401 points by kolyder 6 days ago | 93 comments
  12. Distributed systems programming has stalled (shadaj.me)
    284 points by shadaj 6 days ago | 217 comments
  13. Fire-Flyer File System (3FS) (github.com)
    358 points by wenyuanyu 6 days ago | 100 comments
  14. Ohio One Construction Timeline Update (newsroom.intel.com)
    90 points by ChrisArchitect 5 days ago | 28 comments
  15. McKinsey's Analysis of the Gender Pay Gap: Data Exploration Gone Wrong (substack.com)
    10 points by sarahweaver 1 day ago | 1 comment
  16. Accessing region-locked iOS features, such as EU app stores (downrightnifty.me)
    93 points by todsacerdoti 6 days ago | 2 comments
  17. Putting Andrew Ng's OCR models to the test (runpulse.com)
    124 points by ritvikpandey21 6 days ago | 61 comments
  18. Hydrogen becomes a superfluid at nanoscale, confirming 50-year-old prediction (phys.org)
    45 points by bookofjoe 6 days ago | 2 comments
  19. NASA uses GPS on the moon for the first time (popsci.com)
    7 points by geox 1 day ago | 1 comment
  20. What can be computed? A practical guide to the theory of computation (2018) [pdf] (softouch.on.ca)
    94 points by nill0 6 days ago | 25 comments
  21. HYTRADBOI 2025 Conference Postmortem (scattered-thoughts.net)
    8 points by luu 2 days ago | 1 comment
  22. Digg founder teams up with former Reddit rival to buy and revive website (cnbc.com)
    5 points by bloomingkales 9 hours ago | 4 comments
  23. GLP-1 drugs: An economic disruptor? (2024) (wildfirelabs.substack.com)
    384 points by herbertl 4 days ago | 529 comments
  24. Surgery implants tooth material in eye as scaffolding for lens (cbc.ca)
    151 points by qkeast 6 days ago | 56 comments
  25. Show HN: a Rust library for creating hierarchical state machines (docs.rs)
    38 points by acid_burn 5 days ago | discuss
  26. Broke Studio releases NES game (on cartridge) (brokestudio.fr)
    5 points by HellDunkel 11 hours ago | discuss
  27. GPT-4 Admit to Progressive Restrictions – OpenAI Subsidies Degrading Performance (old.reddit.com)
    4 points by PrixKc 9 hours ago | 1 comment
  28. An equation of state for dense nuclear matter such as neutron stars (phys.org)
    6 points by rbanffy 3 days ago | 1 comment
  29. Type++: Prohibiting Type Confusion with Inline Type Information [pdf] (ndss-symposium.org)
    32 points by pjmlp 6 days ago | 15 comments
  30. Show HN: I built a modern Goodreads alternative (kaguya.io)
    250 points by vasanthk1125 4 days ago | 209 comments
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